Case control study of ANKK1 Taq 1A polymorphism in patients with alcohol dependence classified according to Lesch’s typology* Badania asocjacyjne polimorfizmu Taq1A genu ANKK1 u pacjentów z zespołem zależności alkoholowej według typologii Lescha
نویسندگان
چکیده
1 University of Szczecin, Institute of Psychology, Department of Clinical Psychology and Mental Health, Szczecin, Poland 2University Center for Education, University of Szczecin, Poland 3Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland 4Department of Psychiatry, Vienna University, Austria 5Department of Nursing, Pomeranian Medical University, Szczecin, Poland 6 Institute of Psychiatry and Neurology, Department of Pharmacology, Warszawa, Poland 7 Department of Orthopedics, Pomeranian Medical University, Szczecin, Poland
منابع مشابه
Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1.
BACKGROUND There is an extensive and inconsistent literature on the association of the dopamine D2 receptor gene (DRD2) with alcohol dependence. Conflicting results have been attributed to differences in the severity of the alcohol dependence phenotype across studies, failure to exclude related disorders from comparison groups, and artifacts of population-stratification. Recently the genetic po...
متن کاملSuicidal Behavior and Haplotypes of the Dopamine Receptor Gene (DRD2) and ANKK1 Gene Polymorphisms in Patients with Alcohol Dependence – Preliminary Report
Suicide is a significant public health issue and a major cause of death throughout the world. According to WHO it accounts for almost 2% of deaths worldwide. The etiology of suicidal behavior is complex but the results of many studies suggest that genetic determinants are of significant importance. In our study,--we have analyzed selected SNPs polymorphisms in the DRD2 and ANKK1 genes in patien...
متن کاملImpulsivity-related cognition in alcohol dependence: Is it moderated by DRD2/ANKK1 gene status and executive dysfunction?
Perceived impaired control over alcohol use is a key cognitive construct in alcohol dependence that has been related prospectively to treatment outcome and may mediate the risk for problem drinking conveyed by impulsivity in non-dependent drinkers. The aim of the current study was to investigate whether perceived impaired control may mediate the association between impulsivity-related measures ...
متن کامل[ANKK1 gene in psychiatry].
According to last findings, one of the most commonly studied polymorphisms in psychiatry-Taq1A is located in the ANNK1 (Ankyrin Repeat and Kinase Domain containing 1) gene, not in the dopamine receptor 2 (DRD2) gene. This polymorphism has been extensively studied in relation to alcohol, nicotine and drugs addiction, eating disorders, ADHD, schizophrenia and pharmacogenetics. The ANKK1 gene cont...
متن کاملInfluence of DRD2 and ANKK1 polymorphisms on the manifestation of withdrawal syndrome symptoms in alcohol addiction.
BACKGROUND We investigated the relationship between withdrawal syndrome symptoms and dopamine receptor 2 DRD2 gene polymorphisms-141 C I/D (rs1799732) exon 8 G/A (rs6276) and ANKK1 (Ankyrin Repeat and Kinase Domain Containing 1) gene polymorphism Taq1A (rs1800497). MATERIAL A total number of 213 patients who met the ICD 10 criteria for given phenotypes were enrolled in the study. Those phenot...
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